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Any risks that may be associated with nicotine replacement therapy are substantially outweighed by the well established dangers of continued smoking.
Users should be informed that if they continue to smoke while using the patchesthey may experience increased adverse effects due to the hazards of smokingincluding cardiovascular effects.
In principlethe Nicotinell TTS can cause adverse reactions similar to those associated with nicotine administered by other meansincluding smokingand these are mainly dose dependentSince the maximum plasma concentrations of nicotine that are produced by the patch are lower than those produced by smoking and fluctuate lessnicotine-related adverse reactions occurring during treatment with the patch can be expected to be less marked than during smoking.
Discontinuation of treatment may be advisable in cases of severe or persistent allergic reactions.
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