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There is not enough data from clinical trials to determine the safety and efficacy of digoxin during labor and delivery.

Patients with Wolff-Parkinson-White syndrome who develop atrial fibrillation are at high risk of ventricular fibrillationTreatment of these patients with digoxin leads to greater slowing of conduction in the atrioventricular node than in accessory pathwaysand the risks of rapid ventricular response leading to ventricular fibrillation are thereby increased.

This medicine could be given to the mother to treat abnormally high heart rate and congestive heart failure in the unborn child.

Lanoxin is also used to treat atrial fibrillationa heart rhythm disorder of the atriathe upper chambers of the heart that allow blood to flow into the heart

Hypocalcemia can nullify the effects of digoxin in humansthusdigoxin may be ineffective until serum calcium is restored to normalThese interactions are related to the fact that digoxin affects contractility and excitability of the heart in a manner similar to that of calcium.

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