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Selegiline should not be used in patients who are being treated with antidepressant drugsincluding MAO inhibitorstricyclic antidepressantsserotonin noradrenaline reuptake inhibitorsSNRIvenlafaxineand selective serotonin reuptake inhibitorse.g citalopramescitalopramfluoxetinefluvoxamineparoxetine and sertralineSee section 4.5 interactions
Caution is advised when selegiline is taken in combination with other centrally acting medicinal products and substancesThe concomitant intake of alcohol should be avoided.
Selegiline may be administered either as a single dose in the morning or in two divided doses of 5 mgtaken at breakfast and lunch.
This deteriorating response is currently interpreted as a manifestation of the inability of the ever decreasing population of intact nigrostriatal neurons to synthesize and release adequate amounts of dopamine.
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