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Methemoglobinemia has occurred in premature and full-term neonates who were given overdoses of metoclopramide 1 4 mg kg day orally, intramuscularly or intravenously for 1 3 or more days .

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May impair mental and/or physical abilities required for performance of hazardous tasks such as operating machinery or driving a motor vehicleconcomitant use of central nervous systemCNSdepressants or drugs associated with EPS may increase this effecte.galcoholsedativeshypnoticsopiatesand anxiolyticsavoid drug or the interacting drugdepending on importance of drug to the patient.

Irritable bowel medications such as dicyclomineBentylhyoscyamineAnaspazCystospazLevsinor propanthelinePro-Banthine

Metoclopramide oraltaken by mouthis used for 4 to 12 weeks to treat heartburn caused by gastroesophageal reflux in people who have used other medications without relief.

Can cause tardive dyskinesiasee Black Box Warningsespecially in elderlydiscontinue if signs or symptoms of tardive dyskinesia developmetoclopramide itself may completely or partially suppress these manifestationstardive dyskinesia may persist even after drug is discontinued.

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